1/19/2024 0 Comments Gaba gummies![]() ![]() Initially, it was discovered in plants (Steward et al., 1949), it was then identified in the mammalian brain (Roberts and Frankel, 1950), and subsequently in animals (Roberts and Eidelberg, 1960) and several other organisms-including bacteria and fungi (Bouche et al., 2003). Gamma-aminobutyric acid (GABA) is a four-carbon non-proteinogenic amino acid that is present in bacteria, plants, and vertebrates. Although more studies are needed before any inferences can be made about the efficacy of oral GABA consumption on stress and sleep, results show that there is limited evidence for stress and very limited evidence for sleep benefits of oral GABA intake. Fourteen studies met the criteria and were included in the systematic review. Only placebo-controlled human trials that assessed stress, sleep, and related psychophysiological outcomes as a response to natural GABA (i.e., GABA that is present naturally in foods) or biosynthetic GABA (i.e., GABA that is produced via fermentation) intake were included. We systematically searched on PubMed database for studies published up to February 2020 following PRISMA guidelines. ![]() ![]() We performed a systematic review to examine whether natural and/or biosynthetic oral GABA intake has an effect on stress and sleep. However, although several human clinical trials have been conducted, results regarding the role of natural and/or biosynthetic oral GABA intake on stress and sleep are mixed. GABA's stress-reducing, and sleep enhancing effects have been established. Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. ![]()
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